LONDON (AP) — A book about a wealthy American family whose actions helped unleash the United States’ opioid epidemic won Britain’s leading nonfiction book prize Tuesday.

Patrick Radden Keefe’s “Empire of Pain: The Secret History of the Sackler Dynasty” was awarded the 50,000 pound ($67,000) Baillie Gifford Prize during a ceremony at London’s Science Museum.

Keefe’s book chronicles the billionaire Sackler clan, owner of Purdue Pharma, whose members used their fortune to fund museums and art galleries around the world. A reckoning has come with the revelation that much of that fortune was based on OxyContin, a powerful prescription painkiller that the company developed in the 1990s and marketed aggressively to doctors.

“Empire of Pain” traces the rise of the family’s fortunes under three doctor brothers and their children, and its downfall in a web of lawsuits and bankruptcy proceedings.

Amid protests over its role in the opioid business, the Sackler name has been removed in recent years from wings and galleries at institutions including the Louvre in Paris and the Serpentine Gallery in London. Institutions including Britain’s National Portrait Gallery and the Tate galleries have stopped taking the family’s donations due to its role in the opioid crisis, which has been linked to more than 500,000 deaths in the U.S. alone since 2000.

Some opioid deaths have been attributed to OxyContin and other prescription painkillers, though most are from illicit forms of opioids such as heroin and illegally made fentanyl.

Sackler family members have denied wrongdoing, although their company has pleaded guilty twice to federal crimes over their opioid practices. In September a U.S. federal judge gave conditional approval to a settlement that would remove the family from ownership of Purdue and reorganize the business into a charity-oriented company whose profits would go to government-directed efforts to prevent and treat addiction.

The Baillie Gifford Prize recognizes English-language books from any country in current affairs, history, politics, science, sport, travel, biography, autobiography and the arts.

“Empire of Pain” beat five other finalists: Cal Flyn’s environmental exploration “Islands of Abandonment”; Harald Jähner’s “Aftermath: Life in the Fallout of the Third Reich, 1945-1955”; Kei Miller’s essays on discrimination, “Things I Have Withheld”; John Preston’s media mogul biography “Fall: The Mystery of Robert Maxwell”; and Albanian writer Lea Ypi’s memoir “Free: Coming of Age at the End of History.”

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